Ingredient Research
A salmon-derived polynucleotide (INCI: Sodium DNA) valued in modern skincare for supporting a firmer, smoother and more revitalised-looking complexion.
What Is PDRN?
PDRN (Polydeoxyribonucleotide) is a polynucleotide ingredient derived from purified salmon DNA (Oncorhynchus keta), with the INCI name Sodium DNA. It consists of DNA fragments with a molecular weight between 50-1500 kDa - one of the reasons it has become such a popular active in modern skincare.
In laboratory research, PDRN has been studied for its interaction with the adenosine A2A receptor pathway, which is associated with the skin's fibroblast and collagen activity. In skincare, it is valued for helping the complexion look firmer, smoother and more revitalised.
PDRN has gained significant attention in the beauty industry, particularly in South Korea, where it has become one of the most talked-about ingredients in premium skincare.
Before
After 28 days
~20% softer-looking crow's feet
~20% Softer-Looking Crow's Feet (split-face study)
A recent randomized split-face clinical study evaluated a topical PDRN eye cream applied twice daily.
Study design: Randomised, double-blind, split-face study. 31 women, 28 days, topical PDRN eye cream compared with a retinol cream.
Key results:
- ~20% reduction in the appearance of crow's feet, outperforming the retinol cream
- Supported skin firmness, elasticity and under-eye smoothness
Ye R et al. (2026). PLOS ONE. View study
How PDRN Works: Nucleotide Skin Support
PDRN (polynucleotides derived from salmon DNA; INCI Sodium DNA) is a well-studied ingredient in skin science.
What laboratory research describes:
- Interacts with the adenosine A2A receptor, a pathway associated with the skin's renewal-related activity
- Supplies nucleotides via the salvage pathway, associated with fibroblast and collagen activity
Squadrito F et al. (2017). Frontiers in Pharmacology, 8:224. View on PubMed
Reviewed as a Promising Skin Anti-Aging Ingredient
PDRN has been reviewed in the scientific literature for its role in supporting the look of skin renewal, collagen support and revitalisation.
Reviewed benefits:
- Associated with collagen support and skin revitalisation
- Described as a promising ingredient for the appearance of skin aging
Khan A et al. (2022). Chinese Journal of Plastic and Reconstructive Surgery, 4(4):187-193. View study
Published References
Topical medium-length PDRN enhances dermal extracellular matrix repair in photodamaged skin
Ye R et al., 2026 · PLOS ONE
Pharmacological Activity and Clinical Use of PDRN
Squadrito F et al., 2017 · Frontiers in Pharmacology · 8:224
Polydeoxyribonucleotide: A promising skin anti-aging agent
Khan A et al., 2022 · Chinese Journal of Plastic and Reconstructive Surgery · 4(4):187-193
Applications of Marine Organism-Derived Polydeoxyribonucleotide
Kim TH et al., 2021 · Marine Drugs · 19(6):296
The Effectiveness of Polynucleotides in Esthetic Medicine: A Systematic Review
Lampridou S et al., 2024 · Journal of Cosmetic Dermatology
Frequently Asked Questions
Everything you need to know about PDRN and polynucleotides.
What is PDRN?
PDRN (Polydeoxyribonucleotide) is a polynucleotide ingredient (INCI: Sodium DNA) derived from purified salmon DNA. In skincare it is valued for helping the complexion look firmer, smoother and more revitalised, and has become one of the most popular actives in premium skincare.
How does PDRN benefit the skin?
In skincare, PDRN is valued for helping the skin look firmer, smoother and more revitalised. Laboratory research has associated it with fibroblast and collagen activity and with supporting the look of a healthy moisture barrier, which together contribute to a healthier-looking, more radiant complexion.
Is PDRN safe for topical use?
Yes. PDRN has a well-documented safety and tolerability profile. Topical PDRN formulations are well-tolerated, with no significant adverse effects reported in published studies. The salmon-derived polynucleotides are highly purified and biocompatible with the skin.
Where does PDRN come from?
PDRN is extracted from the sperm cells of Oncorhynchus keta (chum salmon) through a highly controlled purification process. This source was chosen because salmon DNA shares significant structural similarity with human DNA, ensuring excellent biocompatibility. The extraction process removes all proteins and potential allergens, leaving only the purified DNA fragments.
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