Skingenetix Acetyl Hexapeptide-8 Anti-Wrinkle Serum, 30ml - bottle beside its silver carton on a white background

Skingenetix Acetyl Hexapeptide-8 Anti-Wrinkle Serum, 30ml - a model holding the bottle beside their face

Skingenetix Acetyl Hexapeptide-8 Anti-Wrinkle Serum, 30ml - bottle on a stone plinth against a cool grey ground

Skingenetix Acetyl Hexapeptide-8 Anti-Wrinkle Serum, 30ml - macro of the pipette tip with a clear drop of the serum

Skingenetix Acetyl Hexapeptide-8 Anti-Wrinkle Serum, 30ml - a model applying the serum with the glass dropper

Skingenetix Acetyl Hexapeptide-8 Anti-Wrinkle Serum, 30ml - overhead view of the bottle on a rippled silver-grey surface

Acetyl Hexapeptide-8 Anti-Wrinkle Serum

€49,00

A targeted peptide serum that helps visibly relax the look of expression lines around the eyes and forehead.

Acetyl Hexapeptide-8 - a topical peptide for the look of expression lines
Helps soften the look of forehead lines, crow's feet and frown lines
No parabens · no mineral oil · no synthetic fragrance

Best for: expression lines on the forehead and around the eyes, and anyone wanting a gentle, preventative anti-aging step.

Acetyl Hexapeptide-8 is the active behind the well-known trade name Argireline®.

Key Benefits

Relaxes the look of lines - helps visibly soften expression lines around the eyes and forehead
Smoother appearance - for a smoother, more refreshed look over time
Lightweight & layerable - absorbs quickly and sits well under moisturiser
Hydration - hyaluronic acid for a smoother, hydrated feel

What to expect: a smoother, more relaxed look to expression lines that builds with twice-daily use over 4–8 weeks.

How to Use

Use morning and evening. After cleansing, press 3-4 drops onto slightly damp skin, focusing on expression-line areas - the forehead, around the eyes and between the brows. Pat in gently (don't rub), wait about a minute, then follow with your moisturiser and, in the morning, SPF.

Best results build with consistent daily use over several weeks.

Complete the routine: follow with a moisturiser such as the Matrixyl 3000 Pro-Collagen Firming Cream or the Copper Peptide (GHK-Cu) Day Gel-Cream, plus SPF in the morning.

Key Ingredients

Acetyl Hexapeptide-8
Palmitoyl Tripeptide-1 & Tetrapeptide-7
Niacinamide
Ectoin
Hyaluronic Acid

Clinical Research

Clinical research suggests that topical Acetyl Hexapeptide-8 can support the appearance of smoother skin and softened expression lines, including:

48.9% overall anti-wrinkle efficacy vs 0% placebo (randomized trial)
Reduced appearance of expression lines and crow's feet
Smoother, more even-looking skin surface

Formulated at 10% Acetyl Hexapeptide-8, the concentration used in published clinical studies.

Quantity:

Clinically Studied Ingredients

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€49,00

Before and after

Photographed by customers at home, weeks apart.

Before

After

Fenna S

Verified Customer

A monthly buy

Eighth bottle ordered. That probably says it all.

Before

After

Kelly E

Verified Customer

Much smoother

My skin texture has changed more than I expected from this, especially around my cheeks where it was getting a little rough and uneven. It feels really smooth now and has more of a glow. I use two pumps at night followed by my normal moisturiser.

Before

After

Corinne J

Verified Customer

I noticed when I stopped

My skin feels smoother, looks more hydrated and the lines on my forehead aren't as obvious as they used to be. I stopped using it for about a week when the first bottle ran out and actually noticed the difference.

Before

After

June K

Verified Customer

It didn't irritate my skin

I have pretty sensitive skin so this was the thing I was most worried about. No redness, peeling or burning at all for me. I've slowly worked up to using it every night and my face is definitely looking smoother.

Before

After

Meredith H

Verified Customer

Fine lines look better

I'm 55 and mainly bought it for the lines around my mouth and eyes. I've been using it for almost two months and they do look softer, especially around my eyes. I wouldn't say I suddenly look ten years younger, but my skin definitely looks fresher and more even. That's enough for me.

Before

After

Sophie H

Verified Customer

Skin feels great

Really like this. It absorbs quickly and my skin feels super soft afterwards. I've only been using it about three weeks so I can't say much about deep wrinkles yet, but I'm happy with how my face looks.

Before

After

Nicole T

Verified Customer

Around six weeks in

Around six weeks in I started noticing my forehead looked smoother. Then I noticed the skin under my eyes wasn't looking quite so creased in the morning. It could be because it's more hydrated, it could be the serum itself. I don't really care, because it's working for me.

Before

After

Fiona C

Verified Customer

One of the few serums I stick with

Normally I start skincare products, use them religiously for two weeks and then forget about them. Somehow I've actually stuck with this one, probably because it feels nice and doesn't add another complicated step to my routine.

Before

After

Nola S

Verified Customer

I'm actually seeing a difference

I'm 48 and have tried so many serums over the years that I wasn't expecting much. I've been using this about seven weeks now and the little lines on my forehead are definitely softer. Not gone, obviously, but my skin looks smoother in general. I noticed yesterday that I wasn't reaching for as much foundation either.

Frequently Asked Questions

Skingenetix acetyl hexapeptide 8 anti wrinkle serum

Our customer support is available Monday to Friday: 8am-8:30pm.

Average answer time: 24h

What does the Acetyl Hexapeptide-8 Anti-Wrinkle Serum do?

A peptide serum with Acetyl Hexapeptide-8, supporting peptides, niacinamide and ectoin. It helps relax the look of expression lines for smoother-looking skin over time.

What is Acetyl Hexapeptide-8?

Acetyl Hexapeptide-8 is a peptide widely used in skincare and studied for helping to relax the appearance of expression lines such as crow's feet and forehead lines.

When and how do I use it?

Use morning and/or evening on clean skin. Apply a few drops focusing on expression lines (forehead, around the eyes), let it absorb, then follow with moisturiser and SPF 30+ in the morning.

How soon will I see results?

A smoother look to expression lines typically builds over about 4 weeks of consistent twice-daily use.

Can I combine it with other Skingenetix serums?

Yes. It pairs well with the Copper Peptide or Matrixyl 3000 serums, targeting expression lines while they support firmness and smoothness.

Is it suitable for sensitive skin?

Formulated without parabens, mineral oil or added synthetic fragrance, and it includes ectoin, a soothing hydration ingredient. We recommend a patch test first.

How to Use

3 Simple Steps

1. Cleanse

Wash with a gentle, pH-balanced cleanser and pat skin dry.

Close-up of a glass dropper laying a trail of clear Skingenetix Acetyl Hexapeptide-8 serum along a cheekbone, beneath the eye

2. Apply Acetyl Hexapeptide-8 Serum

Apply a few drops to expression lines: forehead, crow's feet and around the mouth. Wait 60 seconds.

Close-up of a woman smoothing a swatch of cream into her cheek with her fingertips

3. Moisturise + SPF

Follow with your moisturiser. Finish with SPF 30+ every morning.

The Skingenetix Standard

High Purity Ingredients

Pharmaceutical-grade actives. No fillers, no fragrance, no compromise.

Multi-Peptide Approach

Each product targets a different biological pathway. Layer safely for comprehensive results - the same principle behind clinical combination therapy.

Backed by Published Research

Every active is chosen from peer-reviewed studies - cited on our research pages.

Clean, Minimal Formulas

No parabens, no mineral oil and no added synthetic fragrance.

Science, Not Hype

Every formula is built on published clinical research - not trends, not influencer hype. That's the difference.

Acetyl Hexapeptide-8 Anti-Wrinkle Serum

Before and after

Frequently Asked Questions

3 Simple Steps

The Skingenetix Standard

Complete Your Routine